Is there an association between increased nuchal translucency and autism?

Methods The study included all singleton infants born in Denmark, who had routine first trimester screening between January 1st 2008 and March 31st 2012. Children were divided into three groups by NT thickness: NT > 99th percentile (group 1), NT 95th-99th percentile (group 2), and NT < 95th percentile (group 3). Follow-up was undertaken for all children at 2 to 6 years of age, depending on date of inclusion. We obtained information on diagnoses of ASDs (childhood autism (CA), Asperger’s syndrome, and atypical autism) from the Danish Psychiatric Central Registry, a nationwide register of inpatient and outpatient contacts to psychiatric departments. Logistic regression was used to estimate the odds ratio (OR) of ASDs for children in groups 1 and 2 compared to those in group 3.